Rigor and reproducibility of research is critical to the advancement of science. Irreproducibility of research, in particular clinical research, is a growing concern as valuable time is wasted pursuing false leads and consuming significant resources, often from publicly-funded federal grantees. 

Various efforts in academia and the scientific community are underway to improve the transparency and robustness in publications and to promote a cultural shift. This presentation will provide an introduction to the problem of irreproducibility, define key terms and concepts, and describe emerging tools and tactics for supporting and encouraging rigor and reproducibility in research. 

The Open Access movement and the latest guidelines and policies from the National Institutes of Health (NIH) will be discussed including new review criteria for grant proposals.

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